These towering hulks carry enough firepower to level a city several times over. Weapons onboard include the long-range missiles nicknamed 'Snow', capable of disintegrating entire enemy vessels in a few shots, M10 AA Guns, a prow-mounted bombardment laser for pinpoint ground strikes, and many other weapons. The cruisers also have 'dispersive armor' which can handle repeated hits from enemy ships, and even provide some defense against the heavy main cannon of the Helghast MAWLR.
In ship-to-ship combat, the ISA Cruisers completely outmatch Helghast Cruisers, with a single cruiser capable of destroying an entire Helghast battlegroup with a single missile barrage. Generally, the only effective means the Helghast have of engaging ISA Cruisers are boarding parties and ground-based orbital defense weapons.
Measuring 700 meters in height, each ISA Cruiser can hold a complement of 7500, including 5000 soldiers, 500 pilots, 1800 support crew, and 200 officers. Propelled by nuclear-powered beam thrusters that double as weapons, Cruisers provide the ISA with the persuasive force it requires to keep rebelling planets in line. In addition, it can store up to 160 Intruder-type landing craft and 30,000 metric tons of ammunition for the ship's main defense cannons .
Designing and constructing the Cruiser was a massive undertaking for the ISA engineers. These ships differ greatly from their UCN counterparts, as they can change their positioning in-flight from combat operations in space to acting as on-station support in atmospheric conditions. An automated deployment system allows the Cruisers to rapidly send Intruder troop transports to a planet's surface, ensuring total planetary containment.
- Arcturus - Participated in Operation Archangel and succesfully evacuated from Helghan.
- Bright Dawn - Destroyed in Operation Archangel.
- Compulsion - Commanded by Captain Mandaloniz. Destroyed by incoming debris from the Dauntless during the evacuation of Helghan.
- Crescent Moon - Bearing the number 85.
- Dauntless - Commanded by Captain Donaggio. Destroyed during the evacuation of Helghast.
- Denver - Bearing the number 14.
- De Ruyter - Bearing the number 17. Participated in Operation Archangel.
- ISC Cassandra - Contained the number 12. Re-purposed as a weapon-based research station. Sent directly into a sun by Shadow Marshall Lucas Kellan.
- ISC Hexis - Classified research station in deep space.
- ISC Rydion - Classified research station in deep space.
- New Sun - Flagship of Operation Archangel, destroyed.
- Moor Time - Bearing the number 98.
- Mora - Bearing the number 23. Participated in Operation Archangel.
- Solar Wind - Commandeered by admiral Alex Grey.
- St. Nicolaas - Bearing the number 29. Participate in Operation Archangel.
- St. Paul - Bearing the number 73.
- Zephyr - Destroyed in Operation Archangel. .